ChemicalBook > CAS DataBase List > FMoc-NH-5(ethylene glycol)-acetic acid
FMoc-NH-5(ethylene glycol)-acetic acid
- Product Name
- FMoc-NH-5(ethylene glycol)-acetic acid
- CAS No.
- 635287-26-2
- Chemical Name
- FMoc-NH-5(ethylene glycol)-acetic acid
- Synonyms
- FmocNH-P5-CH2CO2H;FMoc-NH-PEG5-CH2COOH;Fmoc-PEG5-acetic acid;Fmoc-NH-5(ethylene glycol)-actic acid;FMoc-NH-5(ethylene glycol)-acetic acid;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid;17-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15-pentaoxaheptadecanoic acid;5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-NH-PEG5-CH2COOH(1-(9H-Fluoren-9-ylmethyl) 5,8,11,14,17-pentaoxa-2-azanonadecanedioate);FmocNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester
- CBNumber
- CB42546850
- Molecular Formula
- C27H35NO9
- Formula Weight
- 517.57
- MOL File
- 635287-26-2.mol
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FMoc-NH-5(ethylene glycol)-acetic acid Property
- Boiling point:
- 704.3±60.0 °C(Predicted)
- Density
- 1.224±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.39±0.10(Predicted)
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 0364AP
- Product name
- Fmoc-NH-PEG5-CH2COOH
- Packaging
- 250mg
- Price
- $303
- Updated
- 2021/12/16
ChemPep
- Product number
- 280104
- Product name
- Fmoc-NH-PEG5-CH2COOH
- Packaging
- 1g
- Price
- $306
- Updated
- 2021/12/16
Activate Scientific
- Product number
- AS103968
- Product name
- FmocNH-PEG5-CH2COOH
- Purity
- 95+%
- Packaging
- 1g
- Price
- $413
- Updated
- 2021/12/16
Apolloscientific
- Product number
- BIPG1412
- Product name
- Fmoc-NH-PEG5-CH2COOH
- Packaging
- 500mg
- Price
- $607
- Updated
- 2021/12/16
chempep
- Product number
- 280104
- Product name
- Fmoc-NH-PEG5-CH2COOH
- Purity
- >=95%
- Packaging
- 5g
- Price
- $820
- Updated
- 2021/12/16
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FMoc-NH-5(ethylene glycol)-acetic acid Chemical Properties,Usage,Production
Description
Fmoc-NH-PEG5-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Fmoc-NH-PEG5-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| Cleavable
| Alkyl/ether
| PEGs
|
FMoc-NH-5(ethylene glycol)-acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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FMoc-NH-5(ethylene glycol)-acetic acid Suppliers
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- +1 (888) 615-9178 / (561) 791-8787
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- United States
- ProdList
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